http://en.wikipedia.org/wiki/Wheeler%E2%80%93DeWitt_equation
The Wheeler–DeWitt equation[1] is an attempt to mathematically meld the ideas of quantum mechanics and general relativity, a step toward a theory of quantum gravity. In this approach, time plays no role in the equation, leading to the problem of time.[2] More specifically, the equation describes the quantum version of the Hamiltonian constraint using metric variables. Its commutation relations with the diffeomorphism constraints generate the Bergmann-Komar "group" (which is the diffeomorphism group on-shell, but differs off-shell).
A Mathematical Proof That The Universe Could Have Formed Spontaneously From Nothing?
https://medium.com/the-physics-arxiv-blog/a-mathematical-proof-that-the-universe-could-have-formed-spontaneously-from-nothing-ed7ed0f304a3